Imaged parent items

Vitamin D Status and antibody levels to common viruses in pediatric-onset multiple sclerosis.

Journal: 

Multiple Sclerosis, 2011;17(6):666-71

Background: The relative contribution and interaction of risk factors for multiple sclerosis (MS) have not been evaluated.

Objectives: To determine whether vitamin D status is associated with antibody levels to common viruses in pediatric-onset MS or clinically isolated syndrome (CIS) patients and controls.

Methods: We assessed whether vitamin D status was associated with viral antibody levels to Epstein–Barr virus, cytomegalovirus (CMV), and herpes simplex virus (HSV)-1 or -2 in subjects who demonstrated evidence of remote infection with these viruses and whether these associations differed depending on disease status.

Results: In 140 subjects, vitamin D status was weakly associated with antibody levels to CMV but not to the other viruses. However, there were some interactions between vitamin D status and disease state. Among those with vitamin D sufficiency (≥30 ng/ml), MS/CIS patients had higher antibody levels to Epstein–Barr nuclear antigen-1 than controls. Vitamin D sufficiency was associated with higher CMV antibody levels in MS/CIS subjects but lower CMV antibody levels in controls. Higher vitamin D levels appeared to be associated with higher titers to HSV-2 in MS/CIS patients but not controls.

Conclusions: Vitamin D status may be differentially associated with antibody levels to common childhood viruses among seropositive subjects.

Additional uncaught exception thrown while handling exception.

Original

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Additional

PDOException: SQLSTATE[HY000]: General error: 1015 Can't lock file (errno: 165 - Table is read only): INSERT INTO {watchdog} (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (:db_insert_placeholder_0, :db_insert_placeholder_1, :db_insert_placeholder_2, :db_insert_placeholder_3, :db_insert_placeholder_4, :db_insert_placeholder_5, :db_insert_placeholder_6, :db_insert_placeholder_7, :db_insert_placeholder_8, :db_insert_placeholder_9); Array ( [:db_insert_placeholder_0] => 0 [:db_insert_placeholder_1] => php [:db_insert_placeholder_2] => %type: !message in %function (line %line of %file). [:db_insert_placeholder_3] => a:6:{s:5:"%type";s:12:"PDOException";s:8:"!message";s:354:"SQLSTATE[HY000]: General error: 1015 Can't lock file (errno: 165 - Table is read only): UPDATE {node_counter} SET daycount=daycount + 1, totalcount=totalcount + 1, timestamp=:db_update_placeholder_0 WHERE ( (nid = :db_condition_placeholder_0) ); Array ( [:db_update_placeholder_0] => 1502977295 [:db_condition_placeholder_0] => 1150 ) ";s:9:"%function";s:17:"statistics_exit()";s:5:"%file";s:96:"C:\WampDeveloper\Websites\www.pediatricmscenter.org\webroot\modules\statistics\statistics.module";s:5:"%line";i:73;s:14:"severity_level";i:3;} [:db_insert_placeholder_4] => 3 [:db_insert_placeholder_5] => [:db_insert_placeholder_6] => http://www.pediatricmscenter.org/node/1150 [:db_insert_placeholder_7] => [:db_insert_placeholder_8] => 54.167.231.97 [:db_insert_placeholder_9] => 1502977295 ) in dblog_watchdog() (line 163 of C:\WampDeveloper\Websites\www.pediatricmscenter.org\webroot\modules\dblog\dblog.module).