Imaged parent items

Safety and tolerability of interferon beta-1b in pediatric multiple sclerosis: A Multicenter Study.

Journal: 
Neurology 2006;66:472-6

Background: Immunomodulatory therapies are widely used in adults with multiple sclerosis (MS) and safety and tolerability is well-established. Although at least 5% of all patients with MS experience the clinical onset of their disease prior to age 18 years, the available literature on safety and tolerability of immunomodulatory therapies for pediatric-onset MS is limited.

Methods: The authors retrospectively reviewed safety and tolerability of interferon beta-1b (IFNβ-1b) in a cohort of 43 children and adolescents treated for a mean of 29.2 months (SD 22.3 months).

Results: Mean age at start of IFNβ-1b treatment was 13 years. Eight children were ≤10 years. Most common adverse events included flu-like syndrome (35%), abnormal liver function test (26%), and injection site reaction (21%). No serious or unexpected adverse events were reported.

Conclusions: Although data on long-term effects on the maturing organ systems are lacking, the safety profile supports the safety and tolerability of interferon beta-1b (IFNβ-1b) in children with multiple sclerosis and related diseases. All patients treated with IFNβ-1b should undergo regular monitoring of liver function.

Additional uncaught exception thrown while handling exception.

Original

PDOException: SQLSTATE[HY000]: General error: 1015 Can't lock file (errno: 165 - Table is read only): UPDATE {node_counter} SET daycount=daycount + 1, totalcount=totalcount + 1, timestamp=:db_update_placeholder_0 WHERE ( (nid = :db_condition_placeholder_0) ); Array ( [:db_update_placeholder_0] => 1498307468 [:db_condition_placeholder_0] => 1090 ) in statistics_exit() (line 73 of C:\WampDeveloper\Websites\www.pediatricmscenter.org\webroot\modules\statistics\statistics.module).

Additional

PDOException: SQLSTATE[HY000]: General error: 1015 Can't lock file (errno: 165 - Table is read only): INSERT INTO {watchdog} (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (:db_insert_placeholder_0, :db_insert_placeholder_1, :db_insert_placeholder_2, :db_insert_placeholder_3, :db_insert_placeholder_4, :db_insert_placeholder_5, :db_insert_placeholder_6, :db_insert_placeholder_7, :db_insert_placeholder_8, :db_insert_placeholder_9); Array ( [:db_insert_placeholder_0] => 0 [:db_insert_placeholder_1] => php [:db_insert_placeholder_2] => %type: !message in %function (line %line of %file). [:db_insert_placeholder_3] => a:6:{s:5:"%type";s:12:"PDOException";s:8:"!message";s:354:"SQLSTATE[HY000]: General error: 1015 Can't lock file (errno: 165 - Table is read only): UPDATE {node_counter} SET daycount=daycount + 1, totalcount=totalcount + 1, timestamp=:db_update_placeholder_0 WHERE ( (nid = :db_condition_placeholder_0) ); Array ( [:db_update_placeholder_0] => 1498307468 [:db_condition_placeholder_0] => 1090 ) ";s:9:"%function";s:17:"statistics_exit()";s:5:"%file";s:96:"C:\WampDeveloper\Websites\www.pediatricmscenter.org\webroot\modules\statistics\statistics.module";s:5:"%line";i:73;s:14:"severity_level";i:3;} [:db_insert_placeholder_4] => 3 [:db_insert_placeholder_5] => [:db_insert_placeholder_6] => http://www.pediatricmscenter.org/node/1090 [:db_insert_placeholder_7] => [:db_insert_placeholder_8] => 54.166.201.210 [:db_insert_placeholder_9] => 1498307468 ) in dblog_watchdog() (line 163 of C:\WampDeveloper\Websites\www.pediatricmscenter.org\webroot\modules\dblog\dblog.module).